Acyclovir Extravasation: Case Report and Review of the Literature

Background: Infiltration and extravasation of solutions is a common, under-reported problem with potentially severe morbidity. We report a case of intravenous extravasation of acyclovir and discuss our approach and management of this incident. Methods: We describe a case of acyclovir extravasation and provide a literature review on the general management of extravasation injuries. PubMed articles in the English Language were used for this review. Informed consent was obtained from all individual participants included in the study. Results: Close observation and extremity elevation with cold compresses was an adequate treatment for our patient. At final follow-up, the patient had some residual soft tissue swelling but no functional deficits. Conclusion: Knowledge of general management principles and tailoring treatment based on properties of the solution, amount of solution extravasated, and the overall clinical picture will optimize outcomes of this common and potential sentinel event.